There are three main access points to the cave: Estancia Cueva de las Manos, from Bajo Caracoles (map), and a midway access road between the two points. The cave is most easily reached by a gravel road, which leaves Ruta 40 (Route 40) north of Bajo Caracoles and runs 43 km (27 mi) northeast to the south side of the Pinturas Canyon. The north side of the canyon can be reached by rough, but shorter, roads from Ruta 40. A 3 km (1.9 mi) path connects the two sides of the canyon, but there is no road link.
Cueva de las Manos is named for the hundreds of hand paintings stenciled into multiple collages on the rock walls. The art in the Cueva de las Manos is some of the most important art in the New World, and by far the most famous among rock art in the Patagonian region.
There are also depictions of human beings, guanacos (Lama guanicoe), rheas, felines and other animals, as well as geometric shapes, zigzag patterns, representations of the sun, and hunting scenes. The hunting scenes are naturalistic portrayals of a variety of hunting techniques, including the use of bolas. Similar paintings, though in smaller numbers, can be found in nearby caves. There are also red dots on the ceilings, probably made by submerging their hunting bolas in ink, and then throwing them up.
The main cave is about 66 feet (20 meters) deep, and is composed of the cave itself, two outcroppings, and the walls at either side of the entrance. The entrance faces approximately northeast and is about 50 feet (15 meters) in height by 50 feet (15 meters) wide. The paintings on the cave’s wall span about 200 by 650 feet (61 m × 198 m). The initial height of the cave is 33 ft (10 m).